Local Regulation of Homeostasis Favors Chromosomal Instability

Local Regulation of Homeostasis Favors Chromosomal Instability [15–20]. A major question in cancer genetics is to what extent CIN is an early event and thus a driving force of tumorigenesis or a late-stage consequence [21–25]. CIN

[15–20]. A major question in cancer genetics is to what extent CIN is an early event and thus a driving force of tumorigenesis or a late-stage consequence [21–25]. CIN fitness. The selective cost of CIN, however, can be overcome by an increased probability of generating muta-Fukuoka 812-8581 Japan tions, such as LOH of TSP genes, that enhance the fitness of the cell. Hence, a costly CIN can hit...

I-37: Genome Instability and DNA Damage in Male Somatic and Germ Cells Expressed as Chromosomal Microdeletion and Aneuploidy Is A Major Cause of Male Infertility

Background: Sperm chromatin insufficiencies leading to low sperm count and quality, infertility and transmission of chromosomal microdeletion and aneuploidies to next generations can be due to exposure to environmental pollutions, chemicals and natural or manmade ionizing radiation. In this project which has continued for more than 10 years and is unique in many technical aspects in Iran and in...

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.

TRF2 is a telomere-binding protein with roles in telomere protection and telomere-length regulation. The fact that TRF2 is up-regulated in some human tumors suggests a role of TRF2 in cancer. Mice that overexpress TRF2 in the skin, K5TRF2 mice, show critically short telomeres and are susceptible to UV-induced carcinogenesis as a result of deregulated XPF/ERCC1 activity, a nuclease involved in U...

Human premature aging, DNA repair and RecQ helicases

Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the tissue and organism levels. A number of mechanisms have evolved to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. DNA helicases play important roles in the DNA damage response. The RecQ family of DNA helicases is of particular interest since...

REGULATION OF ACID-BASE HOMEOSTASIS BY THE KIDNEY